Introduction: Sensitizer-induced occupational asthma (OA) has significant health and socioeconomic outcomes in affected subjects.
Objective: To evaluate clinical and functional outcomes of sensitizer-induced OA in bakers and cotton workers three to five years after cessation of exposure to the offending workplace agent.
Methods: We studied 16 patients with sensitizer-induced OA (10 bakers and 6 textile workers), eight males and eight females, aged 32 to 48 years. All study subjects completed a questionnaire and underwent spirometric measurements and metacholine challenge, in the same manner as at the time of diagnosis. The findings obtained were compared with findings registered at the time of diagnosis.
Results: We found significantly lower prevalence of patients with respiratory symptoms in the previous 12 months after the mentioned period of removal from exposure than their prevalence at the time of diagnosis (100% vs. 68.7%; P = 0.014). In regard to nasal symptoms, their prevalence at the time of the study was lower than at the time of diagnosis but statistical significance was not reached (62.5% vs. 37.5%; P = 0.107). The values of spirometric parameters at the time of the study were similar to their values at the time of diagnosis. The level of the non-specific bronchial hyper responsiveness (NSBHR) at the time of the study was improved in all study subjects. The mean value of the provocative concentration 20 (PC 20) at the time of the study was significantly higher than its mean value registered at the time of diagnosis (2.9 vs. 2.1;P = 0.032). However, none subject normalized his/her NSBHR.
Conclusions: Our findings indicate resolution of the respiratory and nasal symptoms in a part of the study subjects. In addition, all study subjects are left with their NSBHR, although all of them improve.
Keywords: Cessation of exposure; Metacholine challenge; Non-specific bronchial hyper responsiveness; Occupation; Questionnaire; Sensitizer; Spirometry
Published on: Jan 19, 2016 Pages: 1-6
Full Text PDF
Full Text HTML
DOI: 10.17352/aprc.000007
CrossMark
Publons
Harvard Library HOLLIS
Search IT
Semantic Scholar
Get Citation
Base Search
Scilit
OAI-PMH
ResearchGate
Academic Microsoft
GrowKudos
Universite de Paris
UW Libraries
SJSU King Library
SJSU King Library
NUS Library
McGill
DET KGL BIBLiOTEK
JCU Discovery
Universidad De Lima
WorldCat
VU on WorldCat
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."